7-Keto has been tested for improving thermogenic activity through the activation of three thermogenic enzymes: Glycerol-3-Phosphate Dehydrogenase, Malic Enzyme and Fatty Acyl CoA Oxidase. In keeping with the biological definition of thermogenesis, all three of these enzyme activations drive energy-producing substrates in a direction of less efficient ATP production relative to heat production. The enzymes have also been shown to promote the elimination of fat stores for energy and heat production. This is the basis for 7-Keto's ability to enhance thermogenesis and, through that mechanism, accelerate the elimination of fat stores for energy.
- A 2007 study demonstrated that administration of 7-Keto to overweight adults in conjunction with a calorie-restricted diet effectively reverses the decline in resting metabolic rate (RMR) normally associated with dieting. 7-Keto demonstrated an ability to increase RMR by 1.4% above baseline levels and demonstrated a 5.4% increase in daily RMR when administered with a calorie-restricted diet.
- 7-Keto achieves this thermogenic effect without cardiovascular or central nervous system side effects, which are commonly seen with stimulant-associated thermogenic agents.
Although the aging process affects all of the segments of the immune system, investigators have identified abnormalities in the cellular, or T-cell, mediated immune function in the elderly. The decline in T-cell immune function is associated with an increased susceptibility to infections. For example, individuals with age-related declines in cellular immunity have an impaired response to influenza vaccine, making them more susceptible to getting the “flu” even though they have had their flu shot. This product supplied in capsule form for ease of use, but is also available in powder under a different listing.